掀掉腫瘤細胞的假面！原來癌細胞靠這招能奸詐逃過一劫

掀掉腫瘤細胞的假面！原來癌細胞靠這招能奸詐逃過一劫

早安健康

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追蹤
永齡醫教
2020年6月7日上午8:00
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腫瘤細胞呀，掀掉你的假面吧！

要如何藉由先天免疫反應來對抗腫瘤細胞呢？

這說起來簡單，做起來⋯⋯，自有硬碰硬的辦法。效果呢？

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腫瘤細胞呀，掀掉你的假面吧！／原文出處

Barkal AA Brewer RE Markovic M Kowarsky M Barkal SA Zaro BW Krishnan V Hatakeyama J Dorigo O Barkal LJ Weissman IL. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. Nature. 2019 Aug;572(7769):392-396. doi: 10.1038/s41586-019-1456-0. Epub 2019 Jul 31.
Panni R.Z. Linehan D.C. & DeNardo D.G. Targeting tumor-infiltrating macrophages to combat cancer. Immunotherapy 5 1075-1087 (2013).
Majeti R. et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 138 286-299 (2009).
Gordon S.R. et al. PD-1 exxpression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Nature 545 495-499 (2017).
Barkal A.A. et al. Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy. Nat Immunol 19 76-84 (2018).
Advani R. et al. CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma. N Engl J Med 379 1711-1721 (2018).
Willingham S.B. et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A 109 6662-6667 (2012).
Barkal A.A. et al. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. Nature 572 392-396 (2019).

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